Tobacco use may worsen NPP symptoms


According to a study published in BMC Cancer.

Researchers analyzed an internet survey of 435 patients with MPN who reported their demographics, disease characteristics, smoking habits and opinions about tobacco use, as well as reported symptoms related to MPN. in the 10-part version of the symptom assessment of myeloproliferative neoplasms. Form.

Tobacco increases the severity of NPP symptoms

“Overall, current and former tobacco users feel worse and have lower quality of life scores than their non-smoking MPN counterparts,” said in an interview with CURE®.

Current and former smokers had higher levels of fatigue and inactivity and had early difficulty satiety and concentration more frequently than non-smokers. Geyer explained that fatigue, appetite suppression and poor functional status are common effects seen in smokers without cancer, but those with NMP may experience it to a worse degree.

“Among malignant tumors, MPN disorders have one of the most difficult symptom load profiles to treat, so the addition of tobacco-induced symptoms only worsens their functional status,” Geyer said.

People who smoked were also more likely to have problems with other substances and to have different views about their cancer.

“People with a history of smoking are also more likely to have problems with other addictive substances such as alcohol, and most don’t think smoking increases their risk of developing cancer,” Geyer said. , noting that she was surprised that smokers were more likely to think vaping was safer than smoking cigarettes. “The reality is that both lead to lung damage, increase the risk of blood clots, and can lead to systemic inflammation which increases cancer risks.”

Stopping is possible

Patients with NMP can improve their quality of life – and potentially their lifespan – by quitting smoking. Geyer said previous research has shown that quitting smoking can improve symptoms over time, but she knows quitting isn’t always easy.

Patients with MPN should contact their healthcare team if they are having difficulty quitting smoking. Geyer also admitted that clinicians can do a better job of bringing the subject up with their patients, especially since smoking can exacerbate cancer-related symptoms.

“Ultimately, any substance that enters the body should be fair game to bring up with a health care provider. Patients with PND should feel empowered to openly discuss their tobacco use and educate themselves about the additional risks this may impose, as well as treatments that may be helpful, ”she said. “With so many useful drugs on the market, helping someone quit smoking is one of the most important health interventions a provider can do.”

Nationally, the United States has made great strides in reducing tobacco use, and Geyer hopes to continue in that direction.

“Increased education and awareness of the harmful effects of tobacco use has had a powerful impact on people’s decisions to quit smoking,” she said. “We hope that studies such as this will prompt patients and providers to consider the drug’s harmful effects on hematologic malignancies and prioritize its treatment at regular intervals.”

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