Switching from cigarettes to e-cigarette alternatives is not associated with improved cardiovascular outcomes

1. Improved cardiovascular disease (CVD) outcomes were seen at 3 months and 6 months after smoking cessation, but with no difference in individuals randomized to receive treatments such as nicotine-containing e-cigarettes, e-cigarettes nicotine-free and nicotine replacement therapy. (TRN).

Level of evidence assessment: 1 (Excellent)

Smoking is a major risk factor for many health problems, including lung cancer and cardiovascular disease (CVD). Although nicotine replacement therapy (NRT) and behavioral encouragement are the most effective for quitting smoking, high relapse rates demonstrate the need for other quitting strategies. For example, e-cigarettes and vaping products are used by 27% of smokers interested in quitting, compared to 18% who use NRT. However, there is little evidence on the effects of e-cigarettes on cardiovascular health. Therefore, this randomized controlled trial aimed to compare cardiovascular disease outcomes at 3 months and 6 months follow-up, for smokers randomized to be treated with nicotine-containing e-cigarettes, nicotine-free e-cigarettes, or NRT. The study population consisted of 248 people who smoked more than 10 cigarettes a day and wanted to quit. Measured cardiovascular outcomes include flow-mediated dilation (%FMD), mean arterial pressure (MAP), and maximal cutaneous vascular conductance (CVCmax) responses to acetyolcholine (ACh) and sodium nitroprusside (SNP). The results showed that the % of foot-and-mouth disease was improved in the 3 groups, at 3 months (β=3.33, 95% CI 2.61-4.05, p = 0.0001) and at 6 months (β=2.69, 95% CI 2.02-3.35, p smoking cessation, but this improvement did not vary significantly between treatment groups.

Click to read the study in BMC Medicine

Picture: PD

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